Methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylate: Guryaha iyo Waxqabadka

Methyl 2,2-difluorobenzo[d][1,3]dioxole-5-carboxylatewaa iskudhis kiimiko ah oo leh caanaha molecular C9H6F2O4 iyo lambarka CAS 773873-95-3. Waxaa sidoo kale loo yaqaan dhowr eray oo isku mid ah, sida methyl 2,2-difluoro-1,3-benzodioxole-5-carboxylate, 2,2-difluorobenzodioxole-5-carboxylic acid methyl ester, iyo EOS-61003. Waxay ka tirsan tahay fasalka xeryahooda heterocyclic oo leh oksijiin hetero-atoms oo keliya.

Ku faantaa nadiifnimada 98% ugu yaraan, xaruntan-farmasiga-farmasiga waa xal isku dhafan oo loogu talagalay warshadaha sida dawooyinka, agrochemicals, iyo cilmi-baarista.

Maqaalkan, waxaanu ku sharxi doonaa sifooyinka alaabta ee faahfaahsan iyo waxqabadka methyl 2,2-difluorobenzo [d] [1,3] dioxole-5-carboxylate, oo ku salaysan xogta la heli karo.

Tilmaamaha Jirka iyo Kiimikada

Methyl 2,2-difluorobenzo [d] [1,3] dioxole-5-carboxylate waa dareere huruud ah oo cirro leh ama mid adag, taas oo ku xidhan heerkulka iyo nadiifnimada. Waxay leedahay miisaan kelli ah 216.14 g/mol iyo cufnaanta 1.5±0.1 g/cm3. Waxay leedahay bar karkarinta 227.4±40.0C at 760 mmHg iyo dhibic flash ah 88.9±22.2 °C. Waxay leedahay cadaadiska uumiga hooseeya ee 0.1±0.4 mmHg at 25°C iyo biyo yar oo milmayn kara oo ah 0.31 g/L at 25°C. Waxay leedahay Log P qiimihiisu yahay 3.43, taasoo tusinaysa inay aad ugu milmi karto dareerayaasha organic ka badan biyaha.

Qaab dhismeedka methyl 2,2-difluorobenzo [d] [1,3] dioxole-5-carboxylate wuxuu ka kooban yahay giraanta benzene oo lagu daray giraanta 1,3-dioxole, oo leh laba atom oo fluorine ah iyo koox karboksilate ah oo ku dheggan giraanta benzene . Joogitaanka atamka fluorine waxay kordhisaa xasilloonida iyo falcelinta xarunta, iyo sidoo kale lipophilicity iyo bioavailability. Kooxda carboxylate waxay u dhaqmi kartaa sidii koox ka tagtay ama nucleophile falcelino kala duwan. Giraanta 1,3-dioxole waxay u dhaqmi kartaa sidii glycol waji-xidhan ama dienophile ee falcelinta cycloaddition.

Badbaadada iyo Wax ka qabashada

Methyl 2,2-difluorobenzo [d] [1,3] dioxole-5-carboxylate waxaa loo kala saaraa inay tahay walax khatar ah iyadoo loo eegayo Nidaamka Kala Saarida iyo Calaamadaynta Kiimikada (GHS). Waxay leedahay odhaahaha soo socda ee khatarta ah iyo bayaannada taxaddarka ah:

H315: Waxay keentaa cuncun maqaarka

• H319: Waxay sababtaa cuncun isha oo daran

H335: Waxa laga yaabaa inay keento cuncun xagga neefsashada ah

P261: Iska ilaali siigada neefsashada/qiiqa/gaaska/ ceeryaamo/ uumiga/ buufiska

• P305+P351+P338: HADDII INDHAHA LAGU JIRO: Si taxadir leh ugu raaci biyo dhowr daqiiqo. Ka saar muraayadaha indhaha, haddii ay jiraan oo ay fududahay in la sameeyo. Sii wad biyo raacida

• P302+P352: HADDII MAQAARKA UU YAHAY: Ku maydh saabuun iyo biyo badan

Qiyaasaha gargaarka koowaad ee methyl 2,2-difluorobenzo [d] [1,3] dioxole-5-carboxylate waa sida soo socota:

• Neefsashada: Haddii la nuugo, bukaanka u wareeji hawo nadiif ah. Haddii neefsashadu kugu adkaato, sii ogsijiinta. Haddii aanad neefsanin, bixi neefsasho macmal ah. Hel daryeel caafimaad

• Taabashada maqaarka: Ka saar dharka wasakhaysan oo maqaarka si fiican ugu raaci saabuun iyo biyo. Haddii aad dareento raaxo darro, raadso daryeel caafimaad

• Indhaha la taabto: Kala saar daboolka indhaha oo ku raaci biyo socda ama milix caadi ah. Raadi daryeel caafimaad oo degdeg ah

• Qaadista: Gargle, ha keenin matag. Raadi daryeel caafimaad oo degdeg ah

Qiyaasaha ilaalinta dabka ee methyl 2,2-difluorobenzo[d] [1,3] dioxole-5-carboxylate waa sida soo socota:

• Wakiilka: Dabka ku dami ceeryaamo biyo ah, budo qalalan, xumbo ama wakiilka kaarboon laba ogsaydhism. Ka fogow isticmaalka biyaha tooska ah si aad u demiso dabka, taas oo keeni karta dareere guban kara oo fidi kara dabka

Khataraha gaarka ah: Wax xog ah lama hayo

• Ka-hortagga dabka iyo tillaabooyinka ilaalinta: Shaqaalaha dabku waa in ay xidhaan qalabka neefsashada, xidhaan dharka dabka oo buuxa, oo ay la dagaalamaan dabka kor u kacaya. Haddi ay suurtagal tahay, weelka dabka ka soo wareeji meel bannaan. Weeladaha ku yaal aagga dabku ka kacay waa in isla markiiba la daadgureeyaa haddii midabkoodu beddelmo ama ay dhawaaq ka soo saaraan qalabka badbaadada. Go'doomi goobta shilku ka dhacay oo ka mamnuuc shaqaalaha aan khusayn inay galaan. Hayso oo daaweyso biyaha dabka si looga hortago wasakhowga deegaanka

Gabagabo

Methyl 2,2-difluorobenzo [d] [1,3] dioxole-5-carboxylate waa dhex dhexaad muhiim ah oo ka mid ah isku dhafka daawada, abuurista alaabta ilaalinta dalagga, iyo cilmi baarista sayniska. Waxay leedahay qaab-dhismeed gaar ah oo leh laba atom oo fluorine ah iyo koox karboksilate ah oo ku dheggan giraanta benzodioxole, kaas oo siinaya xasillooni, falcelin, lipophilicity, iyo bioavailability xarunta. Waxay leedahay milanka biyaha hooseeya iyo cadaadiska uumiga, iyo barta karkarinta dhexdhexaadka ah iyo barta iftiimaya. Waxaa loo kala saaraa inay tahay walax halis ah waxayna u baahan tahay in si habboon loo maareeyo iyo kaydinta. Waxay leedahay codsiyada suurtagalka ah ee warshadaha kala duwan, sida daawooyinka, agrochemicals, cilmi-baarista, iyo kuwa kale.

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